Witness Infection tells the story of two rival mob families who are transferred from the Witness Protection Program to the same city by mistake. Life has always been pretty protected for Carlo Serrelli. But his past is about to come back and bite him. Carlo’s father has kept him out of the deadly mob business by giving him a job at the family dog groomers, while his younger brother, Dominic, has always done the dirty work.
All that is coming to an end as Carlo’s father has to force him into an arranged marriage with the daughter of the rival Miola family boss. Carlo’s two best friends, Gina and Vince, vow to help him get out of this predicament, but they all get in way over their heads when a serious infection starts eating the town. The good news is that Carlo may not have to get married after all — but the bad news is that everyone might die.